Growth Hormone peptide Fragment 176-191 is also known as HGH Frag 176-191 and AOD9604. It is the modified form of the tail end of the Human Growth Hormone (HGH) molecule, known as the C terminal region. It constitutes less than ten percent of the total size of the HGH molecule, which is the fat-reducing part. It doesn’t affect growth or insulin resistance.
It mimics the way natural Growth Hormone regulates fat metabolism but is 12.5 times stronger for weight loss. It does this without affecting blood sugar or growth observed with unmodified Growth Hormone in animal test subjects. Fragment 176-191 has been shown in studies to release fat specifically from obese fat cells but not from lean ones, reduces new fat accumulation in all fat cells, and enhances fat burning.
It has a short half-life with peak concentrations occurring around 15 minutes and no longer than 60 minutes after administration.$97.00
BPC-157 stands for Body Protection Compound. It is also known as Bepecin, PL 14736, and PL10. It is a synthetic stable gastric pentadecapeptide consisting of fifteen amino acids. It is a partial sequence of BPC that is isolated from the gastric juice of humans.
It is synthetic because it doesn’t share similarities with any natural gastric peptides. It is more stable than other peptides and withstands stomach acid degradation for at least 24 hours.
More research is needed to clarify whether BPC-157 has multiple mechanisms of action. Current research in animal test subjects, suggests BPC-157 influences several growth factors usually involved in angiogenesis (the production of blood vessels) and other factors involved in regeneration following damage.
In small rats, it experimentally accelerated the healing of different wounds in tissues such as tendons, ligaments, skeletal muscle, and bone. Currently, it is in a clinical trial for treating inflammatory bowel disease.$97.00
CJC-1295 is a synthetic analog of the Growth Hormone-Releasing Hormone. With a substitution of four amino acids, it is more resistant to proteolytic inactivation by dipeptidyl peptidase IV (DPP-IV). When combined with Drug Affinity Complex (DAC), it prolongs its half-life, as well as the duration of action in test subjects.
Studies in animals (rats, pigs, and dogs) show that serum IGF-I levels increase several days after a single administration of CJC-1295 with DAC. It sustained a dose-dependent stimulation of serum GH and IGF-I levels when injected into healthy subjects at intervals of 1-2 weeks.
It increases plasma levels of growth hormone from somatotropic cells in the pituitary gland of animal test subjects, without altering its pulsation. It doesn’t inhibit the effects of somatostatin.$97.00
Growth Hormone Releasing Peptide-2 is also known as Pralmorelin or KP-102. It is a new 2nd generation synthetic hexapeptide made up of 6 amino acids.
It is closely related to GHRP-6, a hexapeptide of an earlier generation, and shares many similar characteristics. However, it has a stronger growth hormone-releasing action than GHRP-6 based on a study on cultured pituitary cells in animal test subjects, which showed a 10-fold increase in GH secretion.
Studies on animal test subjects suggest that GHRP-2 рlауs а rоlе аѕ аn аgоnіѕt of ghrelin, thе rесеntlу-fоund gut рерtіdе. It stimulates growth hormone secretion, with a slight stimulator effect on Prolactin, ACTH, and Cortisol levels. It also reduces the impact of the hormone somatostatin, which impairs the natural release of growth hormone.
Consequently, GHRP-2 has been shown to increase growth hormone levels and enhances growth performance in animal test subjects.
ABOUT GHRP-6: It belongs in the family of the Growth Hormone secretagogue, meaning that it causes the secretion of growth hormone. It is a synthetic hexapeptide and a met-enkephalin derivative that contains a chain of 6 unnatural D amino acids.
It has no structural similarity with Growth Hormone Releasing Hormone (GHRH) and works by utilizing specific receptors present in cell cultures of the animal pituitary gland or hypothalamus.
GHRP-6 has cytoprotective effects that are non-growth Hormone-related which include neuroprotective, cardioprotective, anti-inflammatory as well as hepatoprotective effects.
Studies in animal test subjects show that GHRP-6 stimulates Ghrelin, “the hunger hormone” through its ghrelin receptor, which in turn signals an increased production of growth hormone (GH) by acting at the level of the pituitary or hypothalamus through a specific receptor different from that of the endogenous Growth Hormone-Releasing Hormone GHRH.
The four parts of the animal test subjects that demonstrate the role of GHRP-6 include the pituitary gland, central nervous system, liver, and stomach.
The pentapeptide Ipamorelin is classified as a GHRP (growth hormone-releasing peptide), which is similar to GHRP-2, GHRP-6, and Hexarelin in stimulating growth hormone (GH) in animal test subjects.
It is the mildest alternative to GHRP-2 or GHRP-6, because it has similar effects on test subjects, and doesn’t come with as many of the side effects which are noted when during trials of other Growth Hormone Releasing Peptides.
Surprisingly, Ipamorelin has not been shown to release adrenocorticotropic hormone (ACTH), prolactin or cortisol in levels significantly different from those observed, following GHRH stimulation.
Іраmоrеlіn mіmісѕ thе GН rеlеаѕіng рерtіdе (GНRР) ghrеlіn bу bіndіng tо thе GНRР rесерtоrѕ аnd асtіvаtіng GН rеlеаѕе.
Іn соntrаѕt tо оthеr соmроundѕ thаt асtіvаtе thе ріtuіtаrу GН ѕуѕtеm, ѕuсh аѕ GHRP-2 and -6, Iраmоrеlіn іѕ mоrе ѕеlесtіvе іn іtѕ асtіvаtіоn. It іѕ аlѕо mеtаbоlіzеd ѕlоwеr thаn оthеr GНRРѕ, mаkіng іt mоrе ѕtаblе аnd thеrеbу еffесtіvе fоr lоngеr.$97.00
Melanotan 2 or MT-2 is a synthetic cyclic heptapeptide analog of Alpha Melanocyte Stimulating Hormone (α-MSH). It has a seven amino acid sequence and is similar to the receptor binding portions of α-MSH and Adrenocorticotropic Hormone (ACTH). It has been shown in trials to function by stimulating an increase in melanin production. Melanin is a brown pigment that causes the skin to become darker in appearance when exposed to UltraViolet rays.
α-MSH acts on a family of five G protein-coupled receptors, namely MC1R – MC5R. In testing it has been anecdotally to have a variety of anti-inflammatory and other effects. Melanocortins such as α-melanocyte-stimulating hormone (α-MSH) can reduce core body temperature and prevent lipopolysaccharide-induced fever producing hypothermia.
Surprisingly Melanotan 2 also has been shown to have aphrodisiac effects in one study done by a major university. Exerting a dose-dependent effect on erections in anesthetized rats. It also has been shown to have excellent fat burning effects and also increases insulin sensitivity.$97.00
Mechano Growth Factor (MGF) is a synthetically manufactured peptide that is an alternative splicing variant of Insulin-like Growth Factor-1 (IGF-1). It serves as a local tissue repair factor that responds to changes in physiological conditions or environmental stimuli inducing muscle cell proliferation. It may function as a neuroprotectant in brain ischemia seen in animal studies.
The level of growth hormone decreases when animals’ age. Several studies show that intensive exercise may stimulate the release of growth hormone in the presence of MGF. This peptide upregulates protein synthesis and activates satellite cells. It is a potent inducer of muscle hypertrophy in experiments.
It has a relatively short half-life of only a few minutes and is often modified to Pegylated-Mechano Growth Factor (PEG-MGF), increasing its stability.