Melanotan 2 or MT-2 is a synthetic cyclic heptapeptide analog of Alpha Melanocyte Stimulating Hormone (α-MSH). It has a seven amino acid sequence and is similar to the receptor binding portions of α-MSH and Adrenocorticotropic Hormone (ACTH). It has been shown in trials to function by stimulating an increase in melanin production. Melanin is a brown pigment that causes the skin to become darker in appearance when exposed to UltraViolet rays.
α-MSH acts on a family of five G protein-coupled receptors, namely MC1R – MC5R. In testing it has been anecdotally to have a variety of anti-inflammatory and other effects. Melanocortins such as α-melanocyte-stimulating hormone (α-MSH) can reduce core body temperature and prevent lipopolysaccharide-induced fever producing hypothermia.
Surprisingly Melanotan 2 also has been shown to have aphrodisiac effects in one study done by a major university. Exerting a dose-dependent effect on erections in anesthetized rats. It also has been shown to have excellent fat burning effects and also increases insulin sensitivity.
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