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Mechano Growth Factor (MGF) is a synthetically manufactured peptide that is an alternative splicing variant of Insulin-like Growth Factor-1 (IGF-1). It serves as a local tissue repair factor that responds to changes in physiological conditions or environmental stimuli inducing muscle cell proliferation. It may function as a neuroprotectant in brain ischemia seen in animal studies.

The level of growth hormone decreases when animals’ age. Several studies show that intensive exercise may stimulate the release of growth hormone in the presence of MGF. This peptide upregulates protein synthesis and activates satellite cells. It is a potent inducer of muscle hypertrophy in experiments.

It has a relatively short half-life of only a few minutes and is often modified to Pegylated-Mechano Growth Factor (PEG-MGF), increasing its stability.

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